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Research Article Open Access
Nonsteroidal and steroidal drugs are generally used to treat inflammation. However, these drugs have side-effects like nausea, vomiting, etc. This lead to search for new anti-inflammatory agents from natural sources, which would be effective and safe. Many plant extracts show a synergistic effect with each other or with modern drugs. The aim of the present study is to evaluate the synergistic anti-inflammatory activity of chloroform extracts of leaves and roots tubers of Lawsonia inermis Linn. and Chlorophytum borivilianum Sant. respectively in albino wistar rats. The synergistic anti-inflammatory activity is evaluated by using plethysmometer. The study is carried out using dose of 200 mg/kg orally for both the extract individually and for combined extract. Both the chloroform extracts produced statistically significant and dose dependent inhibition of edema induced by Brewer’s yeast-induced rat paw edema and Cotton pellet induced granuloma at all doses when compared to the control groups. The percentage inhibition is also noted for the combination of chloroform extract. Both the extracts in combination did not exhibit toxicity in mice when given orally up to the concentration of 2000mg/kg. Statistically processed results support the conclusion, that the combination of extract of Lawsonia inermis Linn. and Chlorophytum borivilianum Sant. (1:1) possesses dose dependent, significant synergestic anti-inflammatory activity against experimentally induced inflammation.
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Author(s): Nitu Singh, Praveen Kumari