alexa Synthesis, Molecular Docking Study and Brine Shrimp Lethality Test of Benzoxazine and Aminomethyl Derivatives from Eugenol | Abstract

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The specific objective of this research is to study the reaction of eugenol with formaldehyde and aniline and to perform in silico and biological activity studies on the obtained products. All the obtained structure compounds was confirmed by 1H-NMR, 13C-NMR, IR, MS and UV-Vis spectroscopic methods and then were tested for biological activity screening using in silico study by Molegro virtual Docker v 5.5 as a software. Docking process was used by Check point kinase 1 receptor (PDB ID: 2YWP) for screening biological anticancer activity. We have been using brine shrimp lethality test (BST) as in vitro study for anticancer activity screening The result of synthesis, compound (2):4-Allyl-2-methoxy-6-((phenylamino)-methyl)phenol, compound (3):6-Allyl-8-methoxy-3-phenyl-3,4-dihydro-2H-benzo-[e][1,3]oxazine and compound (4):6,6'-(Phenylazanediyl)bis(methylene)bis(4-allyl-2-methoxyphenol) were obtained by mannich reaction on eugenol using formaldehyde and aniline was stirred at room temperature for 0,5 h and reflux at 65 oC for 4 h with the yield product were 26 %, 52 % and 18 %. The results of docking process were benzoxazine and aminomethyl derivatives from eugenol have potential as anticancer activity based on their rerank score. The result of BST, It was found that all compounds have potential anticancer activity based on Meyer’s criteria, therefore benzoxazine and aminomethyl derivatives have potential to be further studied for their bioactivity.

To read the full article Peer-reviewed Article PDF image

Author(s): Galih Satrio Putra, Tegar Achsendo Yuniarta, Achmad Syahrani, Marcellino Rudyanto

Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version