alexa Taste Masking of Sitagliptin Phosphate Monohydrate By Ion Exchange Resin and Formulation of Rapidly-Disintegrating Tablets | Abstract
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The purpose of this research was to mask the intensely unpleasant taste of Sitagliptin Phosphate Monohydrateand to formulate a rapid disintegrating tablet (RDT) of the taste-masked drug. Taste masking was done by complexing Sitagliptin Phosphate Monohydrate with Indion 414 in different ratios by the precipitation method. Drug-Resin complexes (DRCs) were tested for drug content, in vitro taste in simulated salivary fluid (SSF) of pH 6.2, and molecular property. Complex that did not release drug in SSF was considered taste-masked and selected for formulation RDTs. The complex with drug-Resin ratio of 1:1 & 1:2 did not show drug release in SSF; therefore, it was selected. The properties of tablets such as tensile strength, wetting time, water absorption ratio, in vitro disintegration time, and disintegration in the oral cavity were investigated to elucidate the wetting and disintegration characteristics of tablets. Crospovidone 8%wt/wt gave the minimum disintegration time. Tablets of batch F2 containing microcrystalline cellulose as Diluent Crospovidone showed faster disintegration, within 25 seconds. Good correlation between in vitro disintegration behavior and in the oral cavity was recognized. Whereas Sitagliptin Phosphate Monohydrate was rated intensely better with a score of 12 for 10 minutes. Tablets of batch F2 also revealed rapid drug release (t90, 7 minutes) in SGF. Thus, results conclusively demonstrated successful masking of taste and rapid disintegration of the formulated tablets in the oral cavity.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): K Surinder, SH Tusharkumar, RP Ezhilmuthu, and KL Senthilkumar

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords