alexa Abstract | The Research on Effect-enhancing and Toxicity-reducing of Rhubarb Total Anthraquinones Caused by Oral Colon-specific Drug Delivery System When Producing Purgative Efficacy
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article Open Access

Abstract

In the present study, we aimed to prepare rhubarb total anthraquinones oral colon-specific drug delivery granules (RTA-OCDD-GN) for delivering rhubarb free anthraquinones to colon. RTA-OCDD-GN was successfully prepared through a double-layer coating process using chitosan as an inner layer and Eudragit S100 as an outer enteric coating layer. The pharmacodynamics and toxicological results showed that RTA-OCDD-GN could produce considerable purgative efficacy with half dosage of rhubarb medical material (RMM), and significantly reduce the nephrotoxicity of anthraquinones compared with RMM. The comparative pharmacokinetics results in vivo gave a preliminary explanation to the mechanism of toxicity attenuation of RTA-OCDD-GN. Taken together, the oral colon-specific delivery system was a useful media to achieve the effect-enhancing and toxicity attenuation of orally administrated rhubarb total anthraquinones.

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Author(s): Lin Zhang, Xiaodong Gu, Hongwei Wei, Xigang Liu, Pei Liu, Jinhua Chang, Qiang Fu, Cuizhe Liu

Keywords

purgative activities, Anthraquinones, Rhubarb, Oral Colon-specific Drug Delivery System

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