alexa Abstract | UFLC method Development for the quantification of carbamazepine in blood samples and an application to Pharmacokinetic study
ISSN ONLINE(2319-8753)PRINT(2347-6710)

International Journal of Innovative Research in Science, Engineering and Technology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


An isocratic simple rapid method has been developed and validated for the determination of carbamazepine (CBZ) in both solution form and blood samples. The assay was performed using an analytical C18 (100 mm×4.6 mm i. d) with a mobile phase consisting of methanol and water (50:50), the flow rate was 1 ml/min and UV detection at 285 nm. The method was found to be specific for CBZ, no interfering peaks were observed with an overall analytical run time of 5 min. Accuracy reported as % recovery were found to be 95.83–103.34% and 93.18–104.49% for inter-day and intra-day accuracies, respectively. Inter-day precision (reproducibility) was found to be 0.22–1.19 SD, while intra-day precision (repeatability) was found to be 0.14–2.12 SD for the samples studied. The calibration curve was found to be linear with the equation y=13474x+16969, with a correlation coefficient of 0.997 (R2) over a concentration range of 0.5–40 lg/ml. The farthest point of quantitation was the least fixation. The system is straightforward and fast and does not require any preparatory treatment of the specimen. The strategy was approved and effectively requested the blood tests to study the medication pharmacokinetic parameters.

To read the full article Peer-reviewed Article PDF image

Author(s): Adukondalu devandla, MadhusudanRao Yamsani, Avinash

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version