alexa Abstract | Utilization of N-Acyl Compounds for the Synthesis of tricyclic and Bridged Heterocyclic Compounds
e-ISSN: 2319-9849

Research & Reviews: Journal of Chemistry
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


N-acyl derivative 4 was prepared via the reaction of methyl anthranilate with ethyl bromoacetate then refluxing the formed amino ester 3 with acetic anhydride. Cyclization of 4 in presences of sodium methoxide and methanol forming 2,4-pyrrolidindione derivative 5. 2,4-Quinolidinone 6 was obtained via cyclization of 4 in dry toluene and sodium hydride. On the other hand, indolinone derivative 9 was obtained by cyclization of 4 in toluene and free from alcohol due to retro Diekmann condensation. On treatment of 9 with sodium hydride, refluxing toluene and in presences of Crown ether gave tricyclic compound 10 which observed to exist in the enole form 11. Also, treatment of 2-pyrrolidinone with trimethylene chlorobromide produced 12 which cyclized using base and solvent to the bridged ring derivatives 13. The acidic hydrolysis of 13 afforded the corresponding amino acid 15. Whereas derivative 16 was obtained by the reaction of 2-pyrrolidinone with ethyl 3-bromopropionate which on cyclization gave azabicyclo[3,2,1]octan-4,8-dione derivative 17. Compound 17 underwent acidic hydrolysis to the amino ketone derivative azepanone hydrochloride 19.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Fawzia Z. El-Ablack, Mohamed A. Waly


2,4-pyrrolidindione, Quinolidinone, Indolinone, Tricyclic compound, Carboxy azepane, Azepanone hydrochloride., Heterocyclic Compounds

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version