"The dietary glucose cannot cross easily the lipid intestinal bilayer of enterocyte. So, specific transporters are required for glucose intestinal absorption. The Na+ /glucose co-transporter (SGLT1) at the enterocyte apical membrane transports glucose into the cell against its concentration gradient. Also, a facilitative Glucose Transporter (GLUT2), transports sugars across the basolateral membrane to the blood. Some studies show evidences that GLUT2 can also be recruited to the Brush-Border Membrane (BBM) in the presence of high glucose concentration in the lumen and can participate in the intestine glucose absorption process dependent glucose transport across of BBM. Also, phloretin is the aglycone of phlorizin and an inhibitor of intestinal glucose transport mediated by GLUT2
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Last date updated on July, 2014