Sepsis is one of the most challenging health problems worldwide. In the USA alone, around three-quarters of a million cases occur every year, and the fatality rate remains between 30% and 50%. A recent report indicates that between 1999 and 2005, sepsis contributed to 6% of all deaths in the United States. Treating sepsis remains problematic, as no effective anti-sepsis drug is currently available. Sepsis is associated with the activation of multiple inflammatory pathways within the host, including the cytokine network and coagulation system. It is a life-threatening disorder resulting from overwhelming systemic inflammatory responses commonly triggered by bacterial infections.
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Last date updated on May, 2021