Cancer stem cells are the rare cells within tumors with the ability to self-renew and give rise to the phenotypically diverse tumor cell population to drive tumorigenesis. Only a small subset of cancer cells is capable of extensive proliferation. The frequency of these in a tumor is highly variable. Cancer stem cells may have different sensitivities to radiation or chemotherapy. The alternative for a researcher is self-archiving(i.e., to publish in a traditional journal, where only subscribers have immediate access, but to make the article available on their personal and/or institutional Web sites (including so-called repositories or archives)), which is a practice allowed by many scholarly journals. Open Access raises practical and policy questions for scholars, publishers, funders, and policymakers alike, including what the return on investment is when paying an article processing fee to publish in an Open Access articles, or whether investments into institutional repositories should be made and whether self-archiving should be made mandatory, as contemplated by some funders
Last date updated on September, 2024