Cancer stem cells are the rare cells within tumors with the ability to self-renew and give rise to the phenotypically diverse tumor cell population to drive tumorigenesis. Only a small subset of cancer cells is capable of extensive proliferation. The frequency of these in a tumor is highly variable. Cancer stem cells may have different sensitivities to radiation or chemotherapy. Review articles are the summary of current state of understanding on a particular research topic. Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications. The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.
Last date updated on July, 2014