Endothelial cells provide the dynamic lining of blood vessels throughout the body and provide many tissue-specific functions, in addition to providing a nonthrombogenic surface for blood cells and conduit for oxygen and nutrient delivery. As might be expected, some endothelial cells are injured or become senescent and are sloughed into the bloodstream and most circulating endothelial cells display evidence of undergoing apoptosis or necrosis. Rare viable circulating endothelial cells that display properties consistent with those of a progenitor cell for the endothelial lineage. Mesenchymal stem/stromal cells (MSCs) are fibroblastoid cells capable of long-term expansion and skeletogenic differentiation. While MSCs are known to originate from neural crest and mesoderm, immediate mesodermal precursors that give rise to MSCs have not been characterized. Peer review refers to the work done during the screening of submitted manuscripts and funding applications. Publications that have not undergone peer review are likely to be regarded with suspicion by academic scholars and professionals.
Last date updated on July, 2014