Diabetic retinopathy is a very frequent microvascular complication of diabetes mellitus (DM); in fact, it is the leading cause of legal blindness in industrialized countries. DR has several pathogenetic steps: initially, glycosylation of structural proteins leads to the loss of pericytes of the retinal vessels; the consequences include bulging (micro-aneurysms) and rupture (micro-haemorrhages) of capillaries, which are associated with the extravasation of fluids and consequent retinal oedema. The consequence of these vascular abnormalities is retinal ischemia, which in turn, releases proangiogenic factors leading to many abnormal new vessels that proliferate and coat the cortical vitreous surface (proliferating DR). During this step, there is a higher risk of massive haemorrhage (vitreous haemorrhage) and tractional retinal detachment; when this damage occurs, the chances of recovering vision are poor. This is the reason why many efforts have been made to both inhibit the growth and block the development of DR; many of these studies have focused on retinal neoangiogenetic factors in order to prevent one of the first steps of DR.
Journal of Steroids & Hormonal Science is an official journal of OMICS group international that publishes the articles related to diabetes retinopathy. The peer review followed by Journal of Steroids & Hormonal Science is single blind peer review process. This sort of review process will enable the authors to make the required manipulations and improve the quality of their work as per the experts opinion
Last date updated on July, 2014