Estrogen is metabolized in liver and excreted to bile. These show effects on different parts of the body such as: In Genitourinary system it causes Stimulation of vaginal epithelial proliferation and superficial cells of epithelium may become dominant in vagina, Decreases the pH of vagina, Increase the ciliary activity and motility in fallopian tubes, In breast it causes development of ducts, Increase the osteoblastic activity in bone and bone mineral density, In Liver it causes Increase SHBG synthesis, decrease antithrombin production, Increase concentration of bile acids and the development of cholelithiasis. Estrogens exert a variety of effects on growth and development of different tissues. The effects of estrogens are mediated via estrogen receptors (ER), intracellular proteins that function as ligand-activated transcription factors and belong to the nuclear receptor superfamily. The journal of Steroids & Hormonal Science publishes the papers on effects of estrogens. The journal is open access where the content is can be accessed freely by the readers and the papers which will be published are assesed by experts for the quality.
Last date updated on June, 2014