Progesterone also known as P4 (pregn-4-ene-3, 20-dione) is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone is synthesized by corpus luteum in the ovaries, near the kidney by the adrenal glands and during in the placenta during pregnancy. Like other steroids, progesterone also consists of four interconnected cyclic hydrocarbons. Ketone and oxygenated functional groups as well as two methyl branches are present in progesterone. Like all steroid hormones, it is hydrophobic in nature. Progesterone is also stored in adipose (fat) tissue. In mammals, like all other steroid hormones, progesterone is synthesized from pregnenolone, which in turn is derived from cholesterol. In humans, progesterone is produced in more amounts during pregnancy. Primarily, the source is the corpus luteum that has been "rescued" by the presence of human chorionic gonadotropins (HCG) from the conceptus.
Journal of Steroids & Hormonal Science publish periodically and contain a series of articles in each published issue. OMICS Group International which is successfully running 700+ peer-reviewed journals and organizing over 100 International Science Conferences annually with the support of 30, 000 editorial board members. OMICS Group International signed an agreement with more than 100 international societies to make health care information Open Access.
Last date updated on July, 2014