Melatonin is an indolamine hormone (N-acetyl-5-methoxytryptamine), synthesized from tryptophan in pinealocytes in a series of four enzymatic steps. It is widely distributed in nature, occurring in plants, fungi and animals, but was only identified in 1958. In humans, melatonin is exclusively involved in the signaling of âtime of dayâ and âtime of yearâ to all tissues in the body. It is primarily synthesized in the pineal gland, but synthesis also occurs in the retina, GIT, skin, bone marrow and lymphocytes, from where it may influence other physiological functions. In lower vertebrates, the pineal gland is photosensitive, and is the site of a self-sustaining circadian clock. In humans, the gland has lost direct photosensitivity, but responds to light via a multisynaptic pathway. In the retina, it acts as a paracrine signal, since it apparently does not enter the circulation from there.
Melatonin related journals publish all the articles within the scope of melatonin. One of the melatonin related journal is Journal of Steroids & Hormonal Science of Omics Group International which publishes all the articles related to hormones. The melatonin related journal is Open access; Peer reviewed and is accessible to authors for free.
Last date updated on January, 2021