Neurosteroids like tetrahydrodeoxycorticosterone (THDOC) and allopregnanolone (ALP) are metabolites of steroids and formed by the action of 5α-reductase type-1 and 3α-hydroxysteroid dehydrogenase enzymes. THDOC and ALP has anticonvulsant, anxiolytic, sedative effects and induces behavioural/health changes during pregnancy and menstruation while, anxiety and depression in epilepsy. Neuroactive steroids are manufactured in the neurons, astrocytes and glial cells and can be produced from the same tissue. The GABA system is one of the many inhibitory systems and present in about 25% of the brain receptors. There are three types of GABA receptors viz. GABAA, GABAB and GABAC. Both of these neuroactive hormones are GABAA receptor agonist which is pentameric and has an ion channel in its center.
Journal of Steroids & Hormonal Science is an official journal of OMICS group international that publishes the articles related to Neurosteroids under a special issue entitled Neurosteroids. The peer review followed by Journal of Steroids & Hormonal Science is single blind peer review process. This sort of review process will enable the authors to make the required manipulations and improve the quality of their work as per the experts opinion.
Last date updated on July, 2014