|Topical corticosteroids preparations are commonly used in the treatment of ocular inflammation. For anterior segment inflammation, topical steroids treatment is usually preferred over systemic steroids owing to its safety, convenience, and low risk of systemic side effects. Although serum drug levels are apparently low in patients receiving topical corticosteroids there may be a change in levels of plasma cortisol and adrenocorticotropic hormone. Fukushima et al. showed in two different publications an early effect on serum glucose levels, within hours, after subconjunctival injection of dexamethasone in diabetic and non-diabetic rats and an early transient increase in blood glucose levels on the day of surgery in diabetic patients.
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