Cerebral vasospasm is one of the most important cerebrovascular events following SAH and characterized by delayed and prolonged contraction of cerebral arteries, which may cause cerebral ischemia and lead to death or neurological deficits in patients with SAH. Therefore, the prevention and treatment of vasospasm have an important role in the management of SAH patients. However, molecular mechanisms, including alterations in gene expression and functional changes in cerebral arteries after SAH that contribute to the development of cerebral vasospasm, remain to be elucidated. The gene microarray method allows simultaneous analysis of the expression of thousands of genes. This technology promises to allow investigation of the entire genome on a single chip so that researchers can obtain a global picture of the interactions among thousands of genes simultaneously. This technique will also provide insight into the underlying mechanisms of many diseases.
Last date updated on July, 2014