The thyroid gland, or simply the thyroid, in vertebrate anatomy, is one of the largest endocrine glands and consists of two connected lobes. The thyroid gland is found in the neck, below the thyroid cartilage. The thyroid gland controls how quickly the body uses energy, makes proteins, and controls how sensitive the body is to other hormones.
Vasculitis is a rare complication of antithyroid drugs reported with propylthiouracil, carbimazole, methimazole and Benzylthiouracil. Benzylthiouracilâinduced Vasculitis are often severe forms with renal or pulmonary involvement, which can be life-threatening if left untreated .We describe the clinical course and medical management of 2 cases of severe vasculitis with alveolar hemorrhage and renal involvement occurred in 2 patients with Gravesâ disease treated by Benzylthiouracil .The frequency of Vasculitis depends on the molecule used. Itâs 75% with Propylthiouracil, 6% with Methimazole, 3% with Carbimazol and 2.7% with Benzylthiouracil.
The onset of manifestations ranges from weeks to months and up to severe years after the initiation of the treatment.
The average age of patients with this complication is 36 years (8-82 years) and they are adults in 81% of cases.
The high incidence of woman reported is explained by the frequency of thyroiditis in woman.
Last date updated on June, 2014