|Tissuechips refer to the complete fundamental functional unit, capable of performing multi biochemical tasks simultaneously. Tissue chips, rather are similar miniaturized units that can replace a tissue or some part of it, enabling the organ to work normally. Tissue chips have been elemental in tissue engineering technology and have proven to be of utmost importance in the same arena.. These solid substrates can be either positively charged just like silicon or glass or can also be consisting of integrated circuitry units that perform best in signal transduction studies. . In order to bind these flat substrates to the grid system, surface chemistry comes into play that fabricates these substrates by way of a covalent bond on the grid. The fabrication method is not as simple as it seen and is effectively carried out by way of robots or high end micro filament technology as the slight displacement in charge could have serious consequences on the overall study in question. Micro fluidic cell culture chips also called Organ on a Chip cell consists of electrical systems that mimics the responses, structures and functions of physiological organs and tissues. These systems can be effectively used to study the behavioural changes in the organs and thereby enhancing the functions of the same in medium.