Î±-tocopherol (Î±-T) out of the 8 major analogues of vitamin E has been a particular focus because of its strong antioxidant properties. Î±-T is enriched in the plasma of humans and higher animals 10-100-fold to an average of 23.2 Î¼M. In Vitamin E isomers, Î±-T is a fat-soluble vitamin, where as it phosphate form, Î±-tocopherol phosphate (Î±-TP) is naturally occurring water-soluble form. Î±-T has strong antioxidant activity, the chromanol OH group in Î±-TP is phosphorylated so that it has no antioxidant activity. Î±-TP acts as a detergent forming a barrier which might inhibit the transfer of free radicals from one polyunsaturated fatty acid. Î±-TP more efficiently modulated atherosclerotic and inflammatory events than Î±-T by reducing THP-1 cell proliferation and expression of the CD36 scavenger receptor. Î±-TP and Î±-T act as lipid mediators modulating signal transduction and gene expression.
Michael Eskin NA
Vitamins and minerals: open access journal is the best journal in the field of nutrition, metabolism mechanism, supplementation and deficiency disorders related to growth and development of living organisms across the globe.
Vitamins and minerals provides the best review process with the two and more expertise reviewers from concerned field in 21 days and tries to publish the best quality of articles pertaining to the scope of the journal.
Last date updated on September, 2020