Î±-tocopherol (Î±-T) out of the 8 major analogues of vitamin E has been a particular focus because of its strong antioxidant properties. Î±-T is enriched in the plasma of humans and higher animals 10-100-fold to an average of 23.2 Î¼M. In Vitamin E isomers, Î±-T is a fat-soluble vitamin, where as it phosphate form, Î±-tocopherol phosphate (Î±-TP) is naturally occurring water-soluble form. Î±-T has strong antioxidant activity, the chromanol OH group in Î±-TP is phosphorylated so that it has no antioxidant activity. Î±-TP acts as a detergent forming a barrier which might inhibit the transfer of free radicals from one polyunsaturated fatty acid. Î±-TP more efficiently modulated atherosclerotic and inflammatory events than Î±-T by reducing THP-1 cell proliferation and expression of the CD36 scavenger receptor. Î±-TP and Î±-T act as lipid mediators modulating signal transduction and gene expression.
Michael Eskin NA
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Vitamins & Minerals peer review journals covers the broader scopes stressing on the topics of hypervitaminosis, hypovitaminosis D, multivitamins, fat soluble vitamins, water soluble vitamins including but not limited to the above discussed fields.
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Last date updated on January, 2021