Atherosclerosis Journals

The International Agency for Research on Cancer (IARC) has determined that people who are overweight or obese are at increased risk of developing several cancer types.The Atherosclerosis Risk in Communities studies (ARIC study) shows that obesity is risk for the development of carotid artery intima-media thickness: this is an index of generalized atherosclerosis. The proposed mechanisms are some immunomudolatry cytokines/chemokines and adipokinedysregulation obesity-related. The aim of the study is to suggest a general hypothesis in pathogenetic mechanism of the increased risk for atherosclerosis and cancer obesity-related. Many factors contribute to the development of atherosclerosis. Under normal conditions, the vessel wall has its own machinery to maintain vascular homeostasis.Hypoadiponectinemia has been associated with coronary lesions and acute coronary syndromes and its involvement in the development of atherosclerosis appears to be more related to the stability of the atherosclerotic plaque than the atherosclerotic burden .Leptin is increased in obesity but leptin resistance more than hyperleptinemia seems contribute to the atherosclerosis development during obesity because of several clinical studies shows that hyperleptinemia predicts acute cardiovascular events independent of traditional risk factors.Nowadays the link between obesity-related inflammation and risk for atherosclerosis development is established in adipokine dysfunction as inflammatory pathogenetic mechanism for arterial vessel wall.In apoliporotein E deficient mice adiponectin reduces atherosclerosis [83]. It has been observed a close association of hypoadiponectinemia with atherosclerosis obliterans and ischemic heart disease and plasma adiponectin concentration in relation to severity of coronary atherosclerosis and cardiovascular risk factors in middle-aged men. (Marcello Camici, Fabio Galetta and Angelo Carpi,Obesity and Increased Risk for Atherosclerosis and Cancer)

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Last date updated on September, 2024