OMICS Group International is an open access online publishing group which has 700+ peer-reviewed journals, organizes 3000+ International Scientific Conferences per year, have around 50,000+ editorial board members and 1000+ Scientific associations. Medical Journals provide a platform for outstanding research around the globe in the field of medicine. These scholarly journals aim to contribute to the progress and application of scientific discoveries, by providing free access to the research information. The published work reaches the general public and the scientific community immediately after publication, thus providing higher citation rates for the author. Medical Journals are supported by 5000 internationally renowned editorial board members and a high quality review board. Medical Journals use online Editorial Manager System for quick and high quality review process. Articles of Medical journals are subjected to peer reviewing and these are included in the standard indexing databases like ISI, Scopus, EBSCO, CAS, HINARI etc. All the articles published in Medical journals are permanently archived in respective peer reviewed journals thus providing unrestricted utilization and requisition of the scientific information.
Survivin appears to function mainly as an anti-apoptotic molecule and its ability to interfere with p53 is one of its most studied molecular action. However, the presence of survivin in the nucleus; its interaction with the mitotic spindle; its secondary localization inside mitochondria; its presence in exosomes in plasma observed exosomal release; and the existence of circulating survivin-encoding mRNA; and the existence of a many alternative mRNA splice variants all paint a complex picture of the moleculeâs possible actions. Although expressed during fetal development. Due to its relatively specific expression in cancer cells, survivin presents a therapeutic target. Immunotherapy by active immunization is one promising means by which survivin-expressing cancer cells can be targeted. Vaccines directed against an intracellular protein, such as survivin, target the post-proteasomal processed, fragments of the molecule which are presented at the cell surface by MHC class I or class II molecules. While the action of exosomalsurvivin is not well understood, it may mediate cellular signaling in some way. Thus, in addition to producing a direct cell-mediated antitumor effect, active specific vaccination against survivin could lead to antibody-mediated interference with these actions. A number of anti-tumor vaccine strategies have used cell-surface target molecules like HER2/neu, EGFR and EGFRvIII which are accessible to both cellular and antibody-mediated immune attack. A number of survivin-targeting immunotherapeutic strategies have been developed to date. Dendritic cell (DC)-based vaccines are attractive due to the tremendous antigen presentation potential of DC. Dendritic cell vaccines pulsed with apoptotic bodies of cells that over-expressed survivin (as well as Her2, CEA, WT1 and MAGE2) have been studied in non-small cell lung cancer (NSCLC). This study showed positive immune responses in 10 of 14 patients, along with anecdotal clinical responses. Several survivin peptide vaccines are also currently under development. Most recently, this peptide vaccine has shown promise in metastatic urothelial cancer where 30 patients had significantly better overall survival compared to controls. This particular vaccine utilizes a very specific epitope that is not present in all survivin forms. (Michael J Ciesielski, JingxinQiu and Robert A Fenstermaker, Survivin as a Cancer Vaccine Target)
Last date updated on December, 2020