|"Drug-resistant mutants can be transmitted to the patients who havenât been exposed to any antiretroviral drugs, which are called transmitted drug resistance (TDR). TDR is an ongoing public health problem all over the world, may increase the risk of virologic failure following combination anti-retroviral therapy (cART) initiation. Therefore, current HIV treatment guidelines recommend resistance testing at entry into HIV care and at cART initiation. However, the stability of these mutants after the transmission to a new host in the absence of selective drug pressure is not known.
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