"2D-PAGE has been recognized as one of the most powerful proteomics modalities, having originally been reported almost 40 years ago. In 2D-PAGE, intact proteins are separated in a gel matrix according to their isoelectric points and molecular weights, which are all unique to individual proteins. The separated proteins are then detected by colorimetric methods such as silver staining. Depending on the separation area, hundreds to thousands of proteins can be observed as individual spots in a single gel image. Intriguing proteins that may provide clues to the molecular backgrounds of diseases can be selected by integrating biological information from samples and protein expression data. These proteins can then be further examined for potential clinical applications.
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Citation: Tani Y, Tajima T, Kawai A, Unuma Y , Kinoshita H, et al. (2014) Evaluation of a Novel Automated Machine, the Auto2D, for Two-Dimensional Gel Electrophoresis. J Proteomics Bioinform 7: 108-111."
Last date updated on November, 2020