"Proteins are assumed to contain all necessary information for unambiguous folding (Anfinsenâs principle). However, ab initio structure prediction is often unsuccessful, as the amino acid sequence itself is not sufficient to guide among endless folding possibilities. It seems logical to attempt to find the âmissingâ information in nucleic acids, specifically in redundant (synonymous) codons and their wobble bases.
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Citation: Biro JC (2014) Suggestion to Upgrade the Canonical Concept of Translation. J Proteomics Bioinform 7: 112-120."
Last date updated on July, 2014