Inflammatory Bowel Disease is a chronic relapsing inflammatory condition that affects the gastrointestinal tract. It is comprised of two major phenotypes, Crohnâs disease and ulcerative colitis. The pathogenesis of IBD is believed to be multifactorial and includes genetic predisposition, immune dysregulation, dysbiosis, and barrier dysfunction caused by different factors one of which is oxidative stress. Oxidative stress arises when there is marked imbalance between the production of reactive oxygen species and their removal by antioxidants. Both animal and human studies link oxidative stress and IBD. The most striking evidence in animal studies comes from genetic knockout mice lacking glutathione peroxidase. These animals develop a crypt destructive colitis similar to UC as early as 11 days of age. Human studies show the presence of excessive reactive oxygen metabolites and antioxidant imbalance in the human gastrointestinal tract.
Paraoxonase Gene Expression in Pediatric Inflammatory Bowel Disease: Razan H Alkhouri, Susan S Baker, Humaira Hashmi, Wensheng Liu, Robert D Baker and Lixin Zhu
Last date updated on July, 2014