alexa Mycoplasma Hyopneumoniae|OMICS International | Journal Of Vaccines And Vaccination

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Mycoplasma Hyopneumoniae

Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia (PEP) that reduces growth rate. Colonization also predisposes the host to more severe infections from secondary pathogens. Vaccines of whole-cell and subunit M. hyopneumoniae have only a partial protective effect against primary or secondary infection. Additionally, the cost of producing the vaccines is very high. Therefore development of an improved vaccine is desirable. The ribonucleotide reductase R2 subunit (NrdF) gene fragment of M. hyopneumoniae has a protective effect on M. hyopneumoniae infection: it induces NrdF-specific lung IgA in mice, and significantly reduced lung lesion scores in pigs. The adhesin P97 is a potential antigen of M. hyopneumoniae, enabling the bacteria to adhere to respiratory ciliated epithelial cells. A repeat region of P97 (P97R1) has been shown to include both cilium- and antibody-binding sites and is reported to function independently from other P97 regions. Immunologic Effect of Attenuated Salmonella enteric Serovar Choleraesuis C501 Expressing Recombinant Mycoplasma hyopneumoniae P97R1 Adhesin and NrdF Antigens in Mice: Hao-Yong Zou, Xiao Fei Wang, Feng-Ying Ma, Pin Chen, Wen-Tao Li, Xin-Jun Liu, Yang Wang and Qi-Gai He
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Last date updated on July, 2014