N. meningitidis is a gram negative coccus that is a major cause of meningitis and septicemia globally, predominantly affecting children and adolescents. Meningococacal meningitis and sepsis are devastating diseases that kills children and young adults within hours despite the availability of effective antibiotics. Mortality and permanent disability rates are high, even under optimal health care conditions has also been associated with these infections. Meningitis caused by bacterial infections is more likely to come with complications such as high mortality and morbidity levels. Among survivors, up to 20% have significant sequelae, including neurologic disability, amputation, and hearing loss. The infections by meningococcal in the United States occur sporadically or in small clusters, and the most common Neisseira meningitidis serogroups involved are B, C, and Y. In some parts of the developing world, most notably across the center of Africa, serogroups A and, more recently, W135 cause severe epidemic disease.
Membrane Protein as Novel Targets for Vaccine Production in Haemophilus influenzae and Neisseria meningitides: Julia Nogueira Varela, MÃ¡rio SÃ©rvulo Izidoro Jr, Luciana Maria de Hollanda and Marcelo Lancellotti
Last date updated on July, 2014