Preventive medicine has been recognized to be a cheaper way of avoiding treatment cost, averting disability and preventing death and vaccines are well known for their role in such. Because they arebio-products, they are affected by storage temperature/conditions and their potency tends to reduce with time. Childhood immunization is one of the most important preventive health actions undertaken to promote childrenâs health. It protects them against the most dangerous childhood diseases. Potency and immunogenicity assays are essential in the quality control of vaccines for human and animal use and are integral parts in biopharmaceutical productsâ life cycle and development. Immunogenicity studies generally provide important information with respect to optimization of adjuvant formulations (where necessary) and the evaluation of immunological characteristics of the antigen including the ability to induce functional antibodies and/ or protection from challenge. While immunogenicity refers to a vaccineâs ability to induce a specific immune response, potency refers to ability to induce a protective immune response. DPT is a class of combination vaccines developed to provide protection against three infectious human diseases: diphtheria, pertussis (whooping cough) and tetanus. The vaccine components include diphtheria and tetanus toxoids, and killed whole Bordetella pertussis cells - the organism that causes pertussis - all adsorbed on insoluble aluminium salts that serve as adjuvants.
Potency/Immunogenicity Profile of DPT Vaccines Used in the Expanded Programme on Immunization in South-East, Nigeria: Oli AN, Agu RU, Nnadozie OJ and Esimone CO
Last date updated on July, 2014