Probiotics have been shown to be immunomodulatory and can affect antibody responses following vaccination. Immunisation is one of the most beneficial and cost-effective disease prevention measures.
However several immunisations are associated with suboptimal seroconversion rates and so the protective effect is not optimal. Oral probiotics given to infants during the period of immunization may improve the seroconversion rates. To date, emphasis has been placed on identifying novel vaccine antigens and adjuvants that induce stronger protective immune responses, as well as developing mucosally administered vaccines. Probiotic bacteria as novel mucosal adjuvantshas engendered a lot of interest due to our increased immunological understanding and the availability of various techniques to enhance existing vaccine specificimmune responses. Probiotic bacteria have been suggested to confer a range of health benefits both in children and adults. Among the possible mechanisms explaining these effects is direct or indirect modulation of the intestinal immune system. Specific probiotic strains have indeed been shown to enhance local immunity through innate cell surface pattern recognition receptors or via direct lymphoid cell activation.
Probiotics and Vaccination in Children: Michele Miraglia del Giudice, Salvatore Leonardi, Francesca Galdo, Annalisa Allegorico, Martina Filippelli, Teresa Arrigo, Carmelo Salpietro, Mario La Rosa, Chiara Valsecchi, Sara Carlotta Tagliacarne , Anna Maria Castellazzi and Gian Luigi Marseglia
Last date updated on July, 2014