Transgenic plant vaccines are genetically engineered plant vaccines in which a selected gene is encoded for the desired antigen and modified which when taken orally elicits a strong immune response in the body. Plant-cellproduced vaccines are inherently safe because they pose no risk of microbiologic contamination associated with animal-derived vaccines and eliminate the risk of pathogenicity, reversion to virulence and shedding. Oral delivery stimulates mucosal immunity (the first line of defense) in the tissues lining the respiratory system and eliminates injection-related hazards. Plants structure may help in maintaining the antigenic property even after degradation in intestine. Plenty of availability of plants makes the vaccine production of low cost apart from low cost in storage and transportation. They act through different mechanism of action mainly stimulating the lymphoid structure in the intestine. There may be development of immunotolerance to vaccine peptide or protein. Consistency of dosage form differs to fruit, plant, and generation of the plant. Stability of vaccine in fruit is not known. Evaluating dosage requirement is tedious in case of plant vaccine. Selection of best plant is difficult. Certain plants like potato cannot be eaten raw and cooking may change the properties of vaccine.
Transgenic Plant Vaccine: A Breakthrough in Immunopharmacotherapeutics: Awale MM, Mody SK, Dudhatra GB, Avinash Kumar, Patel HB, Modi CM, Kamani DR and Chauhan BN
Last date updated on January, 2021