|"The paradigm insists that this excess information is used to provide protection (security backup) against mutations, i.e. alterations in wobble bases should not affect the correct sequence of amino acids in encoded proteins. However, we might expect redundancy even of the 1 st or 2 nd codon residues of the same reason, but this is certainly not the case. It is especially strange if we consider that some proteins are not able to fold correctly, as the amino acid sequence alone is often insufficient to provide correct and sufficient protein folding information. Therefore, research concerning connections between nucleic acid and protein structures and interactions was initiated.
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Citation: Biro JC (2014) Suggestion to Upgrade the Canonical Concept of Translation. J Proteomics Bioinform 7: 112-120."