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Risk Factors for Mortality among COVID-19 Patients: Nationwide Cohort Study of Mongolia
Background: Through this first large retrospective cohort study in Mongolia, we tried to provide some useful information for predicting the character of Coronavirus disease 2019 (COVID-19) patients. Materials and methods: Adult inpatients with COVID-19 were retrospectively analyzed from national, provincial, and municipal healt.. Read More
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A Review on Pathology, Artificial Intelligence and the Explainability Conundrum
Artificial intelligence in medical diagnosis, including pathology, provides unprecedented opportunities. However, the lack of explainability of these systems raises concerns about the proper adoption, accountability and compliance. This article explores the problem of opacity in end-to-end AI systems where pathologists might onl.. Read More
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Peripheral Red Blood Cells Morphology in COVID-19 Patients
COVID-19 pandemic has resulted in global health disaster and posed a great challenge to the suitable measures to contain the disease. The pathogenesis of the disease is still evolving. In the search for the pathogenesis of the virus, little attention has been made to the peripheral blood picture in COVID-19 patients. This study .. Read More
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Background: Ureteropelvic Junction Stenosis (UPJS) is one of the main causes of hydronephrosis caused by Ureteropelvic Junction Obstruction (UPJO) , which can damage renal function in severe cases.We want to explore more possible etiologies of UPJO by means of compare the pathological features of different anatomical sites in th.. Read More
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Diagnostic and Prognostic Implications of AAGAB Expression in Human Breast Cancer
Background: Alpha and Gamma Adaptin Binding protein p34 (AAGAB) was previously reported as a novel on- treatment biomarker can improve prediction of response to neoadjuvant chemotherapy in breast cancer. However, the expression and prognostic value of AAGAB in breast cancer is unknown, the function of AAGAB remains to be elucida.. Read More
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Online Diagnosis-Treatment Department Recommendation based on Machine Learning in China
Objective: At present, the HPV DNA test is used to triage young female patients with abnormal cytology. Still, it is not suitable to precisely identify the population with persistent HPV infection. The purpose of this study was to evaluate the diagnostic value of HPV E6/E7 mRNA test in young women with abnormal cytology by compa.. Read More
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Objective: To analyze the predictive value of Renal Resistance Index (RRI) and Plasma Cystatin C (pCysC) in Pregnancy-Related Acute Kidney Injury (PR-AKI). Methods: This study included 182 pregnant women admitted to the Intensive Care unit (ICU) between May 2016 and June 2021. Intensivists who had received full-time bedside ult.. Read More
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Background: Presently, all malaria diagnostic methods like: Microscopy and Rapid Diagnostic Tests are invasive as they depend on blood samples for malaria diagnosis. Hence this study was aimed at comparing the diagnostic performance characteristics of the novel UMT to the currently used Blood RDT, and to find out the efficacy of.. Read More
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Keloid-specific Gene Expression Profiling for Accurate Diagnostic and Therapeutic Applications
Scars are a heterogeneous disease including normotrophic scars, hypertrophic scars, and keloids. Of these lesions, keloids are a distinct subtype from any other type of scar. Clinically, it causes pain, itching, or tenderness, causing life discomfort and characteristically irreversible. Despite various treatment modalities, res.. Read More
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Cutaneous Humoral Immunity: Vasculitis and Autoimmune Bullous Dermatoses
This mini-review regroups the distinct cutaneous lesions observed in the context of humoral immunity. The specific cutaneous immune responses can be divided in two main groups of diseases: A first group that is in relation with the production of circulating immune complexes and a second group corresponding to the auto-immune dis.. Read More
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The adaptation of digital workflow and Artificial Intelligence (AI) for cytopathology has been hindered by the high variability in the use of cytopathology preparation. ThinPrep and other liquid based preparations were designed with digitization in mind can be easily adapted for both digital pathology and future AI for cytopatho.. Read More
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Significance of Breslow Density as a New Prognostic Feature in Cutaneous Melanoma
Breslow density is a novel biomarker for the assessment of tumor load in cutaneous melanoma cases. Breslow density is measured in the deepest invasive area that Breslow thickness was measured in the formalin-fixed paraffin-embedded sections. The determination of Breslow density is a simple, low-cost, and reproducible method. Int.. Read More
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The intramuscular subtype of Nodular Fasciitis (NF) is rare with lesions normally not more than 2 cm in size and characterized by pseudosarcomatous morphology. This paper presents the case of a 27-year-old man with a large-size intramuscular NF. The patient came for treatment complaining of an increasingly enlarged mass in the l.. Read More
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Antiphospholipid Antibodies in Patients with COVID-19: Trend over Time
Objective: Aim of the study was to investigate whether aPL positivity correlated with thrombosis in COVID-19 patients and whether it was transient or persistent. Methods: We enrolled COVID-19 patients who underwent aPL tests: Lupus Anticoagulant (LA); IgM, IgG, IgA anticardiolipin antibodies (aCL); and IgM, IgG anti-β2-Gly.. Read More
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Post Revised Bethesda System for Reporting Thyroid Cytology 2017 Experience: Lessons Learned
Back ground: BSFRTC is widely adopted in the management of the thyroid nodules. Post implementation experiences and the lessons learned from them is the subject of this short review. Methods: Published experiences and appraisals post BSFRTC reviewed, focusing on the variation in reported ROM, state of Atypia of Undetermined Sig.. Read More
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Background: Finding a diagnosis for rare diseases is a challenge for patients and those treating them. Establishing a uniform methodology for specifying the symptoms of a patient seems useful. This, as well as a database with clinical parameters reported in patients already diagnosed with the corresponding disease or that has le.. Read More
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Neuroendocrine Neoplasms of Breast: A Rare Breast Tumor Worthy of Attention
Background: Neuroendocrine Neoplasms of Breast (NENB) is a rare and under recognized subtype of breast neoplasms. The clinical significance, prognostic risk factors and optimal treatment modalities are limited. This study was focused on clinical and pathological features of 27 NENB cases to improve the understanding of these dis.. Read More
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Objective: At present, the HPV DNA test is used to triage young female patients with abnormal cytology. Still, it is not suitable to precisely identify the population with persistent HPV infection. The purpose of this study was to evaluate the diagnostic value of HPV E6/E7 mRNA test in young women with abnormal cytology by compa.. Read More
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Immunohistochemical Evaluation of 5-Hydroxymethylcytosine (5-hmC) in Breast Phyllodes Tumors
Phyllodes Tumors (PTs) pose a significant diagnostic challenge in breast pathology as histological criteria and cutoffs for grading are complex and arbitrary. Nevertheless, the clinical behavior of PTs varies widely and correlates, in part, with the histological grade. Methylation signatures have gained interest as diagnostic an.. Read More
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The Significance of the Anatomic Pathologist: Diagnosis for Infectious Diseases
In the diagnosis or exclusion of infectious disorders, the anatomic pathologist plays a critical role. The anatomic pathologist's initial responsibility is to evaluate the specimen to see if it has normal or abnormal histology (histopathology). If abnormalities are discovered, the pathologist will define the condition. Reactive .. Read More
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