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Secondary Peripheral Low Grade Chondromasarcoma-Calcaneum
A 27 year old male presented with swelling over left leg ankle since 1 year which was rapidly increased in size in last 4 months. Patients with malignant chondrosarcomas typically present with a history of progressive pain. The pain is constant, patient had history of surgical excision of mass lesion at same site 4 years back .O.. Read More
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Autoimmune Myocarditis Symptoms in Children and its Prevention
Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Autoimmune models of myocarditis were developed in late 1980s to 199s by deveral laboratories. Two main approaches were used to induce disease; either complete Freund's adjuvant.. Read More
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This study was aimed to assess the toxicological profile of Ulva lactuca L . through acute and sub-acute toxicity tests based on the OECD guideline 407. Toxicity assessment of protein extracted from Ulva lactuca L . seaweed was performed. An acute toxicity study was carried out using a single dose of 2000 mg/kg for 28 days and m.. Read More
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Immunologic Perturbations Exerted by Harmine and Foot Shock Stress
Pregnancy is a complex physiological state, in which the effect of any stress multiplies its impacts; in this study, we are interested in the effects of electrical stress on pregnant rats and an attempt to mitigate them using an alkaloid. Pregnant rats were divided into seven groups: control and two treated groups with harmine a.. Read More
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Retinoblastoma (Rb) is a common intraocular malignancy in childhood, due to mutation of RB1 gene, approximately one-third of these tumor are bilateral retinoblastoma, which are more heritable and usually found in younger children. A 4 year old boy presented with swelling of left eye with proptosis and swelling extending up to c.. Read More
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Metabolic abnormalities play a key role in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Different drugs have been used in the clinical practice; however, no current therapeutic disease-modifying intervention exists. The biological effect of ozone (O3) has gained much attention in neurodegenerative disorders, due to i.. Read More
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The presence of intraluminal uterine neoplastic tissue or neoplastic cells in accurately examined Fallopian tubes can pose serious diagnostic problems for pathologists. Indeed, this finding, with the simultaneous presence of neoplastic cells in the intraoperative cytology of peritoneal washing, might suggest the retrograde tran.. Read More
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SARS-CoV-2, caused a series of acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused by this virus was termed COVID-19. The virus is transmittable between humans and has caused pandemic worldwide. The number of death tolls continues to rise and a large number of countries have been forced to do .. Read More
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COVID-19 Specific Management of a Depressed Male: A Case Report
In the rapid and progressive world with fast moving regularities, COVID-19 emerged by comprehending worse effects bringing a sudden pause in every aspect globally. Devastating consequence of this pandemic has not only been inclined towards pathophysiology, but the negative impact holds a cruel role on mental health. The regular .. Read More
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Background: Cancer is an important problem that has serious effects on the quality of life. Despite advances in diagnosis, it still affects millions of people. Ovarian cancer is the most common cause of gynecological cancer deaths; it has a very important place in gynecological oncology. Combination therapy is a treatment method.. Read More
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Background: Endometrial cancer is the most common type of gynecological cancer encountered in developed countries. Combination therapy is a treatment method that combines more than one agent used in treatment. Today it is one of the most important weapons in cancer treatment. In this study, the aim was to examine the sole and co.. Read More
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Primary Abdominal Wall Clear Cell Carcinoma: Case Report and Review of Literature
Background: Endometriosis occurring in a surgical scar is well recognized and occurs mainly in patients with a history of hysterectomy or Caesarean section. Scar endometriosis, as well as endometriosis at other sites, can undergo malignant change. Clear cell carcinoma of the endometrium is a very rare and highly malignant neopla.. Read More
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Direct Paraffin Immunofluorescence: An Alternative for Renal Pathology Diagnosis
The diagnosis of renal pathologies, especially glomerulopathies, requires a clinical suspicion and also the performance of a renal biopsy with its respective histopathological study. This includes light microscopy, electron microscopy and immunofluorescence; all these techniques help us to reach a conclusive diagnosis. Renal im.. Read More
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Vaccines give direct protection by making people less susceptible to sickness or infection. Following the publication of genetic sequence of SARS-CoV-2, the virus that causes COVID-19, sparked a surge in global research and development efforts to produce a vaccine to combat the disease. The enormity of the COVID-19 pandemic's hu.. Read More
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B Cell Lymphoblastic Lymphoma Presenting as a Paravertebral Mass in a Child: A Case Report
Lymphoblastic lymphomas are immature lymphoid malignancies accounting for approximately 30% of non Hodgkin lymphoma in children. Most of these neoplasms originate from T cell precursors while less than 25% of them originate from B lymphoblasts. On histology and immunohistochemistry, lymphoblasts in B lymphoblastic lymphoma (BLL).. Read More
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Maximizing Efficacy with Digital Pathology
A increasing number of labs around the world are adopting digital pathology. Scanning entire slide images of tissue samples, analyzing them, uploading them to a database, and exchanging them with laboratories all over the world is part of the practice. However, while digital pathology is being increasingly adopted across the cou.. Read More
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Recent studies shows how a new regulatory mechanism serves as an important biomarker for diabetes development as well as a possible therapeutic target for its prevention. The most significant pancreatic hormones in target tissues, such as the liver, are glucagon and insulin, which regulate proper glucose levels in response to fo.. Read More
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Effect of RBD Mutation (Y453F) in Spike Glycoprotein of SARS-CoV-2 on Neutralizing Antibody Affinity
Background: Infection with Receptor-Binding Domain (RBD) mutant (Y453F) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from farmed minks is known to widely spread among humans. Methods: We investigated the characteristics of SARS-CoV-2 RBD Y453F mutant using three-dimensional structural analysis. We investi.. Read More
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Characters of Mesothelioma are Changeable
One of the histological features of mesothelioma is co-existence of heterogeneous components in the same tumor. Biphasic subtype of mesothelioma is defined by the criteria that each of epithelioid and sarcomatoid components represent at least 10% of the tumor... Read More
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Proliferating the Scientific Excellence and Revolutions in Laboratory Medicine & Pathology
Pathology is a logical order which includes the investigation of Infections. It supports each part of patient consideration, from symptomatic testing and treatment counsel to utilizing front line hereditary advances and forestalling malady. The entire quintessence of medication lies in Pathology and Microbiology... Read More
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