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Kuijiean Suppress Inflammation in Ulcerative Colitis Rat Models by Phosphorylation Level of HuR
In this study used a TNBS/ethanol method and combinated complex factors established the rat model of ulcerative colitis and treatment with the Xipayi Kuijiean (KJA) to conduct whole process. We detected the expression level of hnRNA and mRNA in the five inflammation factor such as IL-1α, IL-1β, IL-10, IL-17, TNF-α.. Read More
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In Venezuela Trypanosoma evansi is responsible for trypanosomosis that affects equines, canines, bovines and wild animals such as capybaras. The pathology of the infections by this monomorphic trypanosome has been extensively studied by different authors in experimental and field conditions at level of light and electron microsc.. Read More
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The coexistence of synchronous chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in a bone marrow of a patient is a very rare occurrence. To our knowledge, only four publications were reported in the English literature. Herein, we describe a 75 year-old gentleman who presented with fatigue and lethargy of 8 weeks dura.. Read More
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Objective: Despite many randomized controlled trials, it is still not clear whether open appendectomy or laparoscopic appendectomy is the most appropriate surgical approach to acute Appendicitis. It is also widely recognized that laparoscopic removal of appendectomy is a well-established procedure with good outcomes. The aim of .. Read More
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Prognostic and Predictive Values of cell Cycle Proteins Centrosomal Protein 5 (CEPP 5)
Background: Disturbances in the expressions of centrosomal proteins (CEPs) and regulatory proteins that control G1-Sphase transition, like cyclins could participate in dysregulation of cell cycle control that has been incriminated in the pathogenesis of several malignancies. Centrosomal protein 55 (CEP55) has an important role i.. Read More
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Immature Teratoma Involving Lung Tissue in a Newborn
Sacrococcygeal teratoma, the most common fetal-neonatal neoplasia. While mature teratomas is having several well-differentiated mature tissues, immature teratomas consist of components that were not completely differentiated specific to the fetal tissue. Even though it might be seen that a several group of tissues such like bone.. Read More
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Multi-Drug Resistant Gram-Negative Bacteria: Antibiotic-Resistance and New Treatment Strategies
In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections. Diseases caused by carbapenemase-resistant Kp (CR-Kp) represent an emerging threat worldwide due to high mortality rate and limited the.. Read More
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BTG1 Low Expression in Pancreatic Ductal Adenocarcinoma is Associated with a Poorer Prognosis
Objective: BTG1 is a member of the TOB/BTG protein family, which is a transducer of ErbB-2 and TOB2. BTG1 is known to inhibit tumor genesis, but the role of it in pancreatic ductal adenocarcinoma is still unknown. The purpose of this study is to investigate the expression of BTG1 protein in pancreatic ductal adenocarcinoma (PDAC.. Read More
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Background: Trypanosoma evansi is the agent of trypanosomosis that affect domestic and wild animals causing anaemia, degeneration, necrosis and inflammatory processes. This disease is of great concern because it produces growth retardation, loss of body weight, low production of animal proteins and diminished fertility and tract.. Read More
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Coronaviruses (CoVs) have relatively high mutation and RNA recombination rates and undergo rapid crossspecies transmission events in vitro and in vivo. The viruses have evolved diverse strategies to evade, blocking host immune responses, and resulting in an emergence of highly virulent CoVs to cause fatal diseases in human, such.. Read More
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Background: Trypanosoma evansi is the etiological agent of trypanosomosis, a disease of domestic (horses, cattle and goats) and wild (capybara, vampires) animals characterized by anaemia, degeneration, necrosis and inflammatory processes. This disease is of great concern because it produces growth retardation, loss of body weigh.. Read More
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Ultrasound (US)-guided fine needle aspiration biopsy (FNA) is currently the most common diagnostic method for determining surgical cases and preventing unnecessary surgery as it is easy, reliable and cost-effective. However, current multi-center studies indicate that about 5-47% of the cases that have undergone FNA are evaluated.. Read More
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A 17-year girl reported with painful right lower posterior teeth. Orthopantomogram showed unilocular radiolucency with scalloped non-sclerotic border at apical area of non-carious right mandibular molars and premolar. A provisional radiological diagnosis of ameloblastoma or odontogenic keratocyst was given. Histopathological exa.. Read More
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Sarcocystosis is an uncommon zoonotic coccidian protozoal infection caused by Sarcocystis spp. Muscular sarcocystosis have been detected in patients with various types of cancer but co-infection with histoplasmosis has never been reported. We report a 39-year-old woman with active lupus nephritis who presented with hoarseness fo.. Read More
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Mir-27a: A Regulator of Apaf-1, Modulate Proliferation and Apoptosis in Laryngeal Carcinoma
Purpose: APAF-1, a key mediator in cytochrome C-dependent apoptotic pathway, plays a critical role in many cancers. MicroRNA-27a inhibits hypoxia-induced neuronal apoptosis by targeting APAF-1. Whether microRNA-27a participates in carcinogenesis via regulating APAF-1 is not reported. Methods: Laryngeal cancer tissues, Hep2 cell.. Read More
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Synovial sarcomas (SS) are rare soft tissue sarcomas that usually arise near large extremity joints. SS may pose difficult diagnostic challenges on cytology when encountered as a monophasic variant. We report a 27-year-old woman diagnosed with metastatic monophasic synovial sarcoma by a CT-scan guided fine needle aspir.. Read More
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Polymorphisms in Claudin 1 and Claudin 7 in Healthy Individuals in Sweden
Tight junction is the area between epithelial cells that controls the fluid between cells. It consists of three main groups of proteins, transmembrane proteins claudin and occludin, accessory proteins zonula occludence 1,2,3 and cytoskeletal protein Actin. Although their main function is to prevent leakage and diffusion of molec.. Read More
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Dysadherin expressions are associated with the aggressive tumors that show poor prognosis in different types of cancers. Aggressive tumors often presented with infiltrative type of growth pattern in colon cancer and that has been associated with poor prognosis as well. The aim of this was to evaluate Dysadherin expression in pai.. Read More
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Diagnostic Challenges in Pediatric Round Blue Cell Tumors of the Bone
Bone lesions, both neoplastic and non-neoplastic, are common in children. The accurate diagnosis is usually established following tissue sampling with histopathologic examination. However, those entities with predominant small round blue cell morphology can be diagnostically challenging. This review highlights distinctive m.. Read More
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Fusion genes are neoplasia-associated mutations, which play a particularly significant role in tumorgenesis and exhibits great importance for clinical applications in malignant hematological disease and solid tumors. Simultaneously with CNVs, gene fusions are resulting from balanced and unbalanced chromosomal rearrangements. Thu.. Read More
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