The pathogenesis of many neurodegenerative diseases, including Alzheimer's disease (AD) is characterized by protein aggregation into amyloid fibrils. In AD, the fibrils are of the amyloid peptide. The development of new approaches based on nanotechnology for early detection and potential treatment of AD is of high current interest. This review describes a pioneering approach involving the design, synthesis and utilization of new engineered magnetic and non-magnetic nanoparticles for inhibition and acceleration of conformational changes of the fibril-forming proteins, e.g. insulin and amyloid.
OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the support of 50,000+ editorial board members as editorial team and aimed to disseminate the scholarly knowledge to the scientific society.
Last date updated on July, 2014