The pathogenesis of many neurodegenerative diseases, including Alzheimer's disease (AD) is characterized by protein aggregation into amyloid fibrils. In AD, the fibrils are of the amyloid peptide. The development of new approaches based on nanotechnology for early detection and potential treatment of AD is of high current interest. This review describes a pioneering approach involving the design, synthesis and utilization of new engineered magnetic and non-magnetic nanoparticles for inhibition and acceleration of conformational changes of the fibril-forming proteins, e.g. insulin and amyloid.
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Last date updated on July, 2014
