|Cyclooxygenase (COX) is an essential enzyme in the formation of prostaglandins, prostacyclin and thromboxane which are major biological mediators. The symptoms of swelling and pain are relieved by inhibitting COX. Aspirin and ibuprofen are the non-steroidal anti-inflammatory drugs which show their action through inhibition of COX.A journalÂ is aÂ periodical publicationÂ intended to further progress ofÂ science, usually by reporting newÂ research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, andÂ scientific papersÂ across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientificÂ validity. Each such journal article becomes part of the permanent scientific record.