Bioartificial liver (BAL) systems are designed to assist malfunctioning livers in patients with various liver diseases. Such systems are composed of a bioreactor device together with functional hepatocytes. It is expected that almost all liver functions, except for the secretion of bile, would be compensated for by BAL systems. Historically, a variety of cells have been studied as sources for the embedded hepatocytes in BAL applications. For example, primary human hepatocytes, immortalized cell lines of C3A human hepatoblastoma cells, liver progenitor cell line HepaRG and cryopreserved porcine hepatocytes have been researched. Some of them have even been explored in clinical investigations.
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Last date updated on November, 2020