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According to the World Health Organization, neuropsychiatric disorders account for at least 20% of the global burden of illness-related disability, and all represent complex disorders of brain function. The development of neurobiological research is giving another dimension to the understanding and execution in psychiatry. Psychiatry has been continuously evolving and changing. Given the continued ambiguity of the brain-mind relationship, unresolved questions remain of 1) how can, and perhaps should psychiatry proceed to formulate a viable system of characterizing mental normality and abnormality, and 2) how might such formulation affect the scope and tenor of psychiatric practice? Such questions are not esoteric or merely academic.