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A 57-year-old man with IgG, ISS stage II multiple myeloma with normal cytogenetics was treated with vincristine/adriamycin/dexamethasone induction followed by autologous hematopoietic stem cell transplantation and achieved a very good partial response. The patient relapsed 4.5 years later and received bortezomib/dexamethasone treatment, which conferred a very good partial response once again.