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It is common to find NABPs classified as DNA-binding proteins, DNA-binding proteins that specifically bind single-stranded DNA, RNA-binding proteins that bind to single- or double-stranded RNA; as well as proteins that bind specific or non-specifically to nucleic acids. On the other hand, proteins binding to DNA or RNA have been often considered and studied as separate functional classes of NABPs since Transcription Factors (TF) bind to genomic promoters and control target gene expression by activating or repressing RNA polymerase activity, and RNA binding proteins modulate protein expression by regulating the degradation, stability, and translation of target mRNAs.
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