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Mesenchymal stem cells (MSCs) differentiate into various types of cells that can form bone, cartilage, connective tissue, and fat. Obesity is characterized by increased adipocyte number and its hypertrophy with subsequent increase in adipose (fat) tissue formation. The increase in MSC commitment and differentiation into adipose cells, or adipogenesis, contributes to obesity. Therefore, understanding the extracellular factors that could promote or prohibit MSC adipogenesis may have an impact on how to deal with obesity.
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