alexa Influences of Gut Hormones on Hepatocellular Carcinoma

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Influences of Gut Hormones on Hepatocellular Carcinoma

In 2014, HCC is worldwide the fifth most common cancer in men and the seventh one in women, and it represents the third most frequent cause of cancer death [1]. Most patients with HCC have elevated serum alpha fetoprotein (AFP) levels. The incidence of HCC is highest in Asia and Africa, where the major risk factors are hepatitis B and C, cirrhosis, and exposure to environmental carcinogens, such as aflatoxin [1]. The pathogenesis of HCC is a multistep process. The molecular pathways involved include p53, β-catenin, NF-κB [2], MAPK [3], ERK [4], JNK [5], WNT/beta - catenin pathway [6] and PI3K/Akt [7], but the detailed molecular mechanisms of HCC are still poorly understood. It is more interesting to find the roles of hormones in HCC molecular mechanisms.

 

Citation: Huang W (2015) Influences of Gut Hormones on Hepatocellular Carcinoma. Endocrinol Metab Synd 4:155. doi: 10.4172/2161-1017.1000155

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