In 2014, HCC is worldwide the fifth most common cancer in men and the seventh one in women, and it represents the third most frequent cause of cancer death . Most patients with HCC have elevated serum alpha fetoprotein (AFP) levels. The incidence of HCC is highest in Asia and Africa, where the major risk factors are hepatitis B and C, cirrhosis, and exposure to environmental carcinogens, such as aflatoxin . The pathogenesis of HCC is a multistep process. The molecular pathways involved include p53, β-catenin, NF-κB , MAPK , ERK , JNK , WNT/beta - catenin pathway  and PI3K/Akt , but the detailed molecular mechanisms of HCC are still poorly understood. It is more interesting to find the roles of hormones in HCC molecular mechanisms.