The relationship between omega-3 and omega-6 fatty acids, inflammation and disease pathogenesis continues to be a topic of extensive study. To a lesser magnitude omega-9 fatty acids have been considered as potential disease mediators. These fatty acids may work individually, additively or synergistically as precursors and critical elements within metabolic pathways, thus actively influencing and/ or altering membrane fluidity, cell structure, and disease pathogenesis. Research has revealed the relationship between inflammation and the cellular lipidomic (i.e. lipid) and glycomic (i.e. sugar) profiles, genetic regulation and signaling, suggesting that these profiles may be useful clinical diagnostic and therapeutic tools . This review provides a brief synopsis of the structure, function and physiological implications of the omega-3, omega-6 and omega-9 fatty acids in inflammation, hypertension, and Cardiovascular Disease (CVD).