A composite resin containing surface pre-reacted glass ionomer(S-PRG) has become widely used as filler or other dental materials in dental treatment. In this mini-review, we briefly summarizethe antibacterial activities of S-PRG on different oral bacteria. The inhibitory effect of S-PRG on plaque formation in the oral cavity has been observed. Streptococcus mutans adherence has been shown to be inhibited by SPRG. S-PRG is also considered to be effective in caries prevention because S-PRG eluate could inhibit biofilm formation and disrupt salivary mature polymicrobial biofilm. S-PRG eluate has suppressed the protease and gelatinase activities of Porphyromonas gingivalis, which is one of the most important periodontopathic bacteria. Coaggregation by P. gingivali sand Fusobacterium nucleatum was also inhibited by S-PRG eluate. Other work has shown that an endodontic sealer containing S-PRGhad an antibacterial effect on some endodontic bacteria. Oral rinsing with S-PRG eluate was also effective in reducing oral malodor production. In this way, S-PRG has antibacterial effect, and it will be further applied for various dental materials and contribute to preventing oral disease.