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Mammalian zinc transporters âan update on physiological functions

In recent years, a number of mammalian zinc transporters have been molecularly characterized. This has brought about major advances in our understanding of the tight regulation of cellular zinc homeostasis and the pivotal roles zinc transporters play in a variety of biological events. Mammalian zinc transporters are classified into two families: the ZRT, IRT-like protein (ZIP) family and the Zn transporter (ZnT) family. The ZIP family consists of 14 members and facilitates zinc influx into the cytosol from the extracellular and intracellular compartments.

http://www.ncbi.nlm.nih.gov/pubmed/23718971

Courtesy: Kambe et al., 2013

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