alexa Midazolam premedication for Ketamine-induced emergence

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Midazolam premedication for Ketamine-induced emergence

Ketamine is a rapidly acting dissociative anesthetic agent commonly used for short surgical procedures which has the properties of rapid induction, good analgesia, and amnesia with a short recovery period. But it has the limitations of intraoperative cardiovascular stimulation, muscular hypertonia and recovery is often associated with postoperative psychomimetic effects (emergence delirium, unpleasant dreams, and hallucinations). The incidence ranges from 5% to 30% which is mostly dose related.Hence, there is an ever increasing quest to overcome these adverse effects with appropriate medication. Drugs including opiates, neuroleptics, benzodiazepines, physostigmine, and alpha 2 adrenoceptor agonists have been used with varying success to prevent these emergence reactions associated with ketamine administration

 
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