Immunosuppression for tolerance induction

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Immunosuppression for tolerance induction

The delineation of the cellular effectors and the molecular pathways involved in the breakdown of central and peripheral tolerance has promoted interventions as diverse as bone marrow transplantation with or without antibody-based immunosuppression for tolerance induction, transplantation of genetically engineered islets of Langerhans to restore insulin production, embryonic and pancreatic stem cells and non pancreatic progenitors as surrogate beta cells.

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